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National Adaptive Trial for PTSD Related Insomnia

Join our PTSD-related insomnia study to explore new treatments.

Recruiting
18-75 years
All
Phase 3

Veterans with PTSD, a condition often caused by severe trauma, may suffer from insomnia, which makes it hard to sleep. This study will test if medications like trazodone and eszopiclone can help with sleep issues. PTSD can cause nightmares, flashbacks, and irritability. The study will compare these medications with a placebo, which is a pill without medicine, to see if they help. The study will last about 17 weeks, with the first 3 weeks adjusting the medication dose. Participants must be Veterans with PTSD and insomnia, ages 18-75. They'll be randomly given either trazodone, eszopiclone, or placebo.

  • The study requires about 17 weeks of participation.
  • Participants will either receive medication or a placebo.
  • Participants should secure firearms during the study for safety.

Participants must not have certain medical conditions or be in other medical studies. Females must use birth control and agree not to become pregnant during the study. The study will measure changes in sleep and PTSD symptoms, using various scales and questionnaires.

Study details
    Insomnia

NCT03668041

VA Office of Research and Development

1 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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