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Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Join our study to explore long-term safety of pembrolizumab in advanced tumors.

Recruiting
18 years and older
All
Phase 3

This study is focused on the long-term safety and effectiveness of a medicine called pembrolizumab, for people with advanced tumors. Pembrolizumab, also known as MK-3475, is a treatment that helps the immune system fight cancer. The study has three parts: the First Course Phase, the Survival Follow-up Phase, and the Second Course Phase. Participants may need to receive pembrolizumab or a related combination treatment every 3 or 6 weeks. Some might get up to 35 doses over two years. The study is for those who were already involved in earlier pembrolizumab studies. They must be healthy enough to participate, not pregnant, and agree to use birth control if needed.

  • Length: Participation might last up to two years, depending on the treatment phase.
  • Visits: Regular visits every 3 or 6 weeks for treatment are required.
  • Risks: Possible side effects include hypersensitivity and other health issues; careful monitoring will be provided.
Study details
    Solid Tumors
    Hematologic Malignancies

NCT03486873

Merck Sharp & Dohme LLC

18 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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