This study is for adults with advanced or metastatic solid tumors, like ovarian or breast cancer. It tests a new medicine called NKT3447. "Advanced" means the cancer has spread, and "metastatic" means it has spread to other body parts. The study has two parts: Dose Escalation and Dose Expansion. The first part finds the safest dose, and the second tests how well it works, especially for ovarian cancer with a specific genetic change called CCNE1 amplification.
To join, you must have cancer that can't be removed by surgery and has gotten worse after other treatments. You must be able to take pills. You can't join if your cancer can be cured by surgery or if you have other serious health conditions.
- The study is in two parts, each testing different things about the medicine.
- You must have tried other treatments first, and this study checks if the new medicine works better.
- Eligible participants need a specific type of genetic change in their cancer.
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