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Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer

Trying high-dose radiation with standard treatment for advanced lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is about treating a type of lung cancer called non-small cell lung cancer (NSCLC) that can’t be treated with surgery. It tests if adding a special high-dose radiation called stereotactic body radiation therapy (SBRT) to regular treatment (which includes regular radiation, chemotherapy, and immunotherapy) works better. SBRT uses special machines to aim radiation very precisely at the tumor, which might need fewer sessions and cause less harm to healthy parts of the body. The regular treatment uses drugs like cisplatin and carboplatin that stop cancer cells from growing. The study compares the usual treatment to adding SBRT to see which works better.

  • Participants will be randomly assigned to two groups: one with SBRT and one with regular treatment.
  • Study involves regular hospital visits for treatments and check-ups over several years.
  • Participants can get regular chemotherapy and immunotherapy, with check-ups every few months.
Study details
    Locally Advanced Lung Non-Small Cell Carcinoma
    Stage IIB Lung Cancer AJCC v8
    Stage III Lung Cancer AJCC v8

NCT05624996

NRG Oncology

11 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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