PediDOSE Study aims to improve how paramedics treat seizures in children during ambulance rides. Seizures happen when there's sudden, uncontrolled electrical activity in the brain, causing changes in behavior, movements, or feelings. Paramedics usually give a medicine called midazolam to stop seizures. However, about one-third of kids still have seizures upon reaching the hospital. This can be due to wrong dose calculations or delays in giving the medicine. In this study, paramedics will use a new method where midazolam doses are based on a child’s age. This means no calculations are needed, and medicine can be given faster using a shot or nasal spray. The study takes place across 20 cities and aims to see if this new way is safer and stops seizures more effectively than current methods.

• The study tests if age-based dosing is safer and more effective.
• Conducted in 20 cities with staggered involvement.
• Participants should not have midazolam allergies, pregnancy, or severe growth issues.