This study is testing a new medicine called **BHV-7000** to see if it helps people with **Major Depressive Disorder (MDD)**, which is a condition where someone feels very sad for a long time. **Monotherapy** means using this medicine alone, without other depression medicines. To join, you must be 18 to 75 years old and have been feeling very sad for at least 2 months. You can't take more than two other medicines for depression during the study and will need to stop other depression medications. Pregnant or breastfeeding women can't join. The study checks if BHV-7000 works well and is safe.

• The study is for adults aged 18 to 75 with moderate to severe depression.
• Participants must stop other depression medications before starting.
• Pregnant or breastfeeding women cannot join the study.