This study is testing a new medicine called VX-147 for people with a kidney problem caused by a gene called APOL1. This study will check if the medicine works well, is safe, and how the body processes it. APOL1-mediated proteinuric kidney disease means the kidneys leak too much protein due to the APOL1 gene. The study includes both adults and children.

• Participants need to have a certain type of APOL1 gene and proteinuric kidney disease.
• Cannot join if you've had a transplant, have uncontrolled high blood pressure, diabetes, or other known kidney diseases.
• The study lasts several months, and there will be multiple visits to the study site.

Before joining, think about the time commitment and any risks. It's important to talk to your doctor and family to see if this study is right for you. There might be compensation for your participation, but you should fully understand what the study involves before deciding.