This study explores a treatment called sotorasib for people with advanced solid tumors that have a specific gene change called KRAS p.G12C mutation. A mutation is like a small change in the DNA that can sometimes cause cancer. The study checks if sotorasib is safe and can be tolerated by people with this mutation. Participants need to be adults (18+ years) and have a certain type of advanced cancer confirmed by lab tests. However, if you have certain conditions like a primary brain tumor, recent heart attack, or issues swallowing pills, you cannot join.

• The study is for adults who are 18 years or older with specific gene changes in their tumors.
• Participants will be monitored for safety and how well they tolerate the treatment.
• Certain health conditions may prevent you from joining the study, such as specific brain issues or recent heart problems.