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Ondansetron As a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial

Exploring ondansetron to ease propofol injection pain in kids.

Recruiting
2-17 years
All
Phase 2

This study is to see if giving Zofran (a medicine used to prevent nausea) before propofol (a drug used to help start anesthesia) can reduce pain from propofol injection in children. Propofol often causes discomfort when injected through an IV (a tube that delivers medicine directly into a vein). The study will be conducted at Children's Healthcare of Atlanta at Egleston and includes children aged 2-17 having surgery with an IV. Participants will be randomly assigned to receive either Zofran or lidocaine (a common pain relief method). During the study, doctors giving anesthesia won't know which group a child is in until after the propofol is given. Every child will receive Zofran at some point during their surgery. No compensation is provided, and participation involves only the time during surgery. The goal is to improve pain control for children undergoing anesthesia.

  • The study is only during surgery time.
  • No payment for participating.
  • Children aged 2-17 can join if they meet eligibility.
Study details
    Injection Site Irritation

NCT05378113

Emory University

1 April 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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