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A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Exploring new treatments for non-small cell lung cancer.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for people with non-small cell lung cancer (NSCLC) who have had their tumor completely removed. The study compares a new treatment, V940 plus pembrolizumab, against a placebo (a fake treatment) plus pembrolizumab. The goal is to see if V940 plus pembrolizumab helps patients stay cancer-free longer.

Key Terms:

  • NSCLC: A common type of lung cancer that grows slowly.
  • Pembrolizumab: A medicine that helps the immune system fight cancer.
  • Placebo: A treatment that looks like medicine but has no active ingredients.

Key Points:

  • The study involves several visits to the clinic.
  • There may be side effects, as with any medical treatment.
  • Participation is voluntary, and patients can leave the study anytime.

To join, patients must have Stage II or III NSCLC, have completed surgery, and received chemotherapy. Those with other serious health issues, ongoing infections, or different types of cancer cannot participate. This study might help find better ways to treat lung cancer in the future.

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Study details
    Non-small Cell Lung Cancer

NCT06077760

Merck Sharp & Dohme LLC

28 June 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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