Study Summary:

This study is for children and young adults with a specific type of brain tumor called non-germinomatous germ cell tumors (NGGCT) that hasn't spread to other parts of the brain or body. The study aims to find the best way to use chemotherapy and radiation therapy (RT) by checking how the tumor responds to the initial chemotherapy. Chemotherapy uses special drugs to stop cancer cells from growing. Radiation therapy uses high-energy rays to kill cancer cells. Based on how well the tumor responds, doctors will decide the next steps: some may get radiation to certain parts of the brain and spine, while others may receive more chemotherapy and a stem cell transplant before radiation.

• Participation involves several rounds of chemotherapy and possibly radiation over a few weeks to months.
• Regular hospital visits for treatment and tests are required.
• Study follows participants for up to 10 years to track their health.

Eligibility: Children and young adults aged 3 to 30, newly diagnosed with NGGCT, and meeting specific health criteria can participate. This includes having certain medical tests and agreeing to follow study rules.