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A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Study of Dabrafenib, Trametinib, and Hydroxychloroquine for specific brain tumors.

Recruiting
1-30 years
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a combination of three drugs - dabrafenib, trametinib, and hydroxychloroquine - on brain tumors in children and young adults. These tumors have a specific genetic change called a BRAF aberration, which means there's a problem in the BRAF gene that can make tumors grow. The drugs work by stopping tumor cells from growing or dividing. The study is split into two parts: Phase I will find the best dose, and Phase II will see how well the drugs work. Participants will take the drugs for up to 2 years, as long as the drugs are helping and side effects are manageable. Phase I will help determine the safest doses for Phase II, where patients will continue receiving the drug combination. People who want to join must have had a certain type of cancer treatment before and meet specific health requirements.

  • The study lasts up to 2 years, with treatments given daily in 28-day cycles.
  • Participants will need to visit the study site for tests and check-ups.
  • Eligibility includes having specific genetic changes and prior specific cancer treatments.
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Study details
    Low Grade Glioma (LGG) of Brain With BRAF Aberration
    High Grade Glioma (HGG) of the Brain With BRAF Aberration
    Low Grade Glioma of Brain With Neurofibromatosis Type 1

NCT04201457

Pediatric Brain Tumor Consortium

2 February 2025

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