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First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

Trial for advanced lung cancer with specific gene mutations.

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new drug, **BAY2927088**, to help people with advanced non-small cell lung cancer (NSCLC). NSCLC is a type of lung cancer that spreads to other parts of the body. Researchers are focusing on people with changes in certain genes (EGFR and HER2) that may cause the cancer to grow faster. BAY2927088 aims to block these changes, potentially stopping cancer's spread.

The study will check if BAY2927088 is safe and determine the best dose. Participants will take the medicine for 3-week cycles, with up to 5 doctor visits per cycle. They might take BAY2927088 once or twice a day as a liquid or tablet. Doctors will monitor participants' health through blood and urine tests, cancer scans like CT and MRI, and by asking about any side effects.

  • Participants must have already tried other cancer treatments without success.
  • Participants will continue taking the drug until their cancer worsens or they experience significant side effects.
  • Potential risks include serious health problems that might lead to hospitalization.
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Study details
    Advanced Non-small Cell Lung Cancer
    EGFR Mutation
    HER2 Mutation

NCT05099172

Bayer

29 December 2024

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