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AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department

Azithromycin trial for preschoolers with severe wheezing in the ER.

Recruiting
18-60 years
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study explores if the antibiotic **Azithromycin (AZ)** can help preschoolers with **severe wheezing**. Wheezing is a whistling sound made when breathing. The study is **double-blind**, meaning neither the doctors nor the participants know who is receiving the actual medicine or a **placebo** (a fake treatment). Participants will take AZ once daily for 5 days. The study will check if AZ helps reduce wheezing, especially for kids with certain bacteria in their noses.

Families will keep an **Asthma Flare-up Diary for Young Children (ADYC)** to record daily symptoms. Some kids will have two extra check-ups after the initial visit to see how they respond to the medicine. **Eligibility** includes children aged 18-60 months with wheezing verified by medical professionals. Kids with recent infections or certain medical conditions can't join.

  • The study will last for about 21 days, with 3 planned visits for some participants.
  • Participants must record symptoms daily using a diary.
  • New medicines or treatments cannot be used 30 days before the study.
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Study details
    Asthma
    Wheezing

NCT04669288

University of Arizona

12 October 2024

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