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Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Exploring Type 1 Diabetes, muscle issues, and Sirtuin-1's role.

Recruiting
18 years and older
All
Phase N/A

This study looks at how a supplement called resveratrol can help people with type 1 diabetes (T1D). T1D is a type of diabetes where the body doesn’t make insulin, a hormone that helps control blood sugar. Resveratrol is thought to improve the function of the endothelin-B receptor (ETBR) and mitochondria in muscles. ETBR helps blood circulation, and mitochondria are like tiny power plants in cells. The study will last for 12 weeks. Participants will take either resveratrol or a placebo, which is a harmless pill that doesn’t do anything. The study will use special tools, like near-infrared spectroscopy (NIRS), to check muscle function without hurting the skin.

  • The study lasts 12 weeks with resveratrol or placebo treatment.
  • Participants must have type 1 diabetes but not other major diseases.
  • Regular visits are needed to monitor progress and effects.

Adults with T1D who don't have other major health issues can join. If you have any major health problems or are pregnant, you should not participate. This study could help improve muscle and heart health in people with T1D.

Study details
    Type 1 Diabetes

NCT04449198

Augusta University

1 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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