Sickle Cell Disease (SCD) is a disorder that affects the red blood cells, causing them to be shaped like a sickle or crescent rather than round. This can lead to episodes of pain and other complications. The SCD-CARRE trial aims to see if a treatment called automated exchange blood transfusion, which replaces the patient's blood with healthy donor blood, helps reduce the number of health problems and hospital visits for adults with high-risk SCD over a year.
People with SCD often have problems with their heart and lungs, which can be checked using tests like NT-proBNP (a blood test) and Doppler-echocardiography (a type of ultrasound for the heart). This study will involve 150 adults and compare their health outcomes with those who only receive standard care.
- Study Length: 12 months
- Eligibility: Adults 18+ with certain SCD types and test results
- Risks: Possible reactions to blood transfusions
If you decide to join, you'll need to have stable SCD medication doses and be off certain drugs for a set time before starting.