The remedē System Therapy Study is a research study to gather information about the safety and effectiveness of the remedē System for people with central sleep apnea (CSA). Central sleep apnea is a condition where your brain doesn't send the correct signals to breathe during sleep. This study is looking for at least 500 people with moderate to severe CSA, which means they have at least 15 breathing pauses per hour during sleep. Participants must be 18 years or older and cannot be pregnant or planning to become pregnant. You need to agree to the study's rules and sign a consent form approved by an ethics committee. The study takes place at around 50 locations in the United States and Europe.

• Duration: The study will involve multiple visits to the study locations over time.
• Participation: You cannot be part of another study that would interfere with this one.
• Safety: The study is to ensure the system is safe and works well in real-world settings.