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Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

Comparing zanubrutinib treatments for older patients with untreated mantle cell lymphoma.

Recruiting
60 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for older patients with Mantle Cell Lymphoma (MCL), a type of blood cancer. The trial explores two ways to use a drug called zanubrutinib, which stops cancer cells from growing. Patients first receive zanubrutinib and rituximab, a medicine that helps stop cancer cells from growing. If the cancer is in full remission, patients are split into two groups. Group A keeps taking zanubrutinib, while Group B stops until cancer shows up again.

Key Points:

  • All patients receive initial treatment with zanubrutinib and rituximab.
  • Participants must be 60+ years old with certain health conditions.
  • Study involves regular medical check-ups and imaging tests for up to 10 years.

Participants can't join if they have certain heart problems or infections like active Hepatitis B or C. They must not have had certain types of cancer treatments before. The study will also look at patients' quality of life and any side effects from the medication. If you join, you will have regular visits and tests, and it's important to follow the instructions for taking the medicine.

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Study details
    Mantle Cell Lymphoma

NCT05976763

Alliance for Clinical Trials in Oncology

6 April 2025

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