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Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Trial: Partial match bone marrow transplant for severe aplastic anemia patients.

Recruiting
1-75 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Severe aplastic anemia is a serious condition where the bone marrow doesn't make enough blood cells. This study tests a special type of bone marrow transplant called haploidentical transplant, using mismatched family donors. Patients first take medicines like Fludarabine, Cyclophosphamide, and get a treatment called TBI (Total Body Irradiation) to prepare their bodies. After the transplant, Cyclophosphamide is given on Days 3 & 4 to help the body accept the new bone marrow. Medicines called Tacrolimus and MMF are then used to prevent rejection of the new marrow. MMF stops on Day 35, but Tacrolimus continues until Day 180. The study aims to see if this method has less than 30% failure.

  • Involves multiple visits over 180 days for treatment and monitoring.
  • Patients must have a family donor with a partial match.
  • Risks include potential graft failure and side effects from the medicines.

Eligibility requires specific health conditions and age limits, and certain health issues may exclude participation.

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Study details
    Severe Aplastic Anemia

NCT02828592

Northside Hospital, Inc.

20 April 2025

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