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Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Trying Nivolumab, maybe with Ipilimumab, for specific recurring uterine cancer.

Recruiting
18 years and older
Female
Phase 2

This study is checking if a combination of two drugs, nivolumab and ipilimumab, works better than nivolumab alone to shrink tumors in a type of endometrial cancer called **dMMR** recurrent endometrial carcinoma. **dMMR** stands for "deficient mismatch repair," which means the body's system for fixing damaged DNA isn't working well. **Nivolumab** and **ipilimumab** are **monoclonal antibodies** that can help the immune system fight cancer.

  • The study involves regular visits for treatment every 3-4 weeks.
  • Participants may need to provide tissue and blood samples, and undergo CT or MRI scans.
  • There is follow-up every 3 months for 2 years, then every 6 months for 3 more years.

If you have this specific type of cancer, meet the eligibility criteria, and are interested in participating, the study could provide access to new treatment options. Participants will be monitored closely and must be willing to follow the treatment and sampling schedule. Additionally, women who can have children must agree to use birth control during the study. Always discuss with your doctor to understand the potential risks and benefits before deciding to join.

Study details
    Endometrial Adenocarcinoma
    Endometrial Clear Cell Adenocarcinoma
    Endometrial Dedifferentiated Carcinoma
    Endometrial Endometrioid Adenocarcinoma
    Endometrial Mixed Cell Adenocarcinoma
    Endometrial Mucinous Adenocarcinoma
    Endometrial Undifferentiated Carcinoma
    Endometrioid Adenocarcinoma
    Recurrent Endometrial Carcinoma

NCT05112601

National Cancer Institute (NCI)

11 May 2025

Step 1 Get in touch with the nearest study center
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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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