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Liquid Biopsy in Ewing Sarcoma and Osteosarcoma As a Prognostic and Response Diagnostic: LEOPARD

Study on liquid biopsy for Ewing Sarcoma and Osteosarcoma diagnosis.

Recruiting
12-50 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at whether a blood test can help predict if certain bone cancers, like **Ewing sarcoma** and **osteosarcoma**, will come back. The test checks for small pieces of tumor DNA, called **circulating tumor DNA (ctDNA)**, in your blood. The study has two parts. In Part A, you'll give blood samples at specific times, but you won't get the results. About 90 people will join this part. In Part B, the results will be shared with you and your doctor. This part involves about 60 people with Ewing sarcoma. The study is funded by the **Dana-Farber Cancer Institute** and other partners.

  • This study involves giving blood samples at certain times.
  • Part B will share test results with you and your doctor.
  • Participants must be aged between 1 and 50 years and meet specific medical criteria.
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Study details
    Ewing Sarcoma
    Ewing Sarcoma of Bone
    Ewing Sarcoma of Soft Tissue
    Peripheral Primitive Neuroectodermal Tumor
    Peripheral Primitive Neuroectodermal Tumor of Bone
    Peripheral Primitive Neuroectodermal Tumor of Soft Tissue
    High-grade Osteosarcoma

NCT06068075

Dana-Farber Cancer Institute

1 April 2025

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