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Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Testing Osimertinib, with or without Bevacizumab, for EGFR-mutant lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is exploring treatments for non-small cell lung cancer with a mutation in the EGFR gene. The EGFR gene helps cells grow and divide. When mutated, it can cause cancer cells to grow faster. Osimertinib is a drug that blocks EGFR, potentially slowing cancer growth. Bevacizumab is another drug that stops blood vessels from forming around the tumor, cutting off its nutrients. This study aims to find out if combining these two drugs is better than using osimertinib alone.

  • Participating involves taking osimertinib daily and possibly bevacizumab every 21 days. The study lasts several years with follow-ups.
  • Eligibility requires a specific type of lung cancer with an EGFR mutation and no prior treatment with certain drugs.
  • Risks include side effects from the drugs; however, potential benefits include longer cancer control.

Participants will undergo regular scans and tests. The study is for adults over 18 and requires a commitment to attend regular check-ups and follow protocols. If you are interested, discuss with your doctor to see if you qualify.

Study details
    Advanced Lung Non-Squamous Non-Small Cell Carcinoma
    Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
    Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
    Stage IIIB Lung Cancer AJCC v8
    Stage IV Lung Cancer AJCC v8

NCT04181060

National Cancer Institute (NCI)

28 June 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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