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A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Exploring Lepodisiran's impact on heart health in adults with high Lp(a).

Recruiting
18 years and older
All
Phase 3

Study Overview: This study looks at a new medicine called lepodisiran. It checks if this medicine can lower the risk of bad heart problems, like heart attacks or strokes, in people with high levels of something called lipoprotein(a) in their blood. The medicine is given as an injection under the skin.

Who Can Join: Adults with high lipoprotein(a) (175 or more nanomoles per liter) who already have heart disease or are at risk, and meet certain age and health criteria, may be eligible. People who had recent major heart events or surgeries, have uncontrolled high blood pressure, or severe kidney or liver issues cannot join.

  • Duration: The study involves multiple visits over a period of time to monitor health and medicine effects.
  • Safety: Participants should be aware of potential risks, including side effects from the medicine.
  • Compensation: Participants might receive compensation for their time and involvement.

Before joining, discuss with your doctor to ensure it's a good fit for your health needs.

Study details
    Atherosclerotic Cardiovascular Disease (ASCVD)
    Elevated Lp(a)

NCT06292013

Eli Lilly and Company

27 April 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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