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AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma

Testing AZD0305 for relapsed/refractory multiple myeloma treatment options.

Recruiting
18 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

AZD0305 Study for Multiple Myeloma: This study tests a new drug, AZD0305, for people with relapsed/refractory multiple myeloma (RRMM), which is a type of blood cancer that comes back or doesn't respond to treatment. AZD0305 is given alone or with other cancer drugs to see if it is safe and works well. The study has two main parts: dose escalation to find a safe amount to give, and dose expansion to learn more about its effects. Participants must have tried at least three other treatments, including specific cancer drugs.

  • Participants must be 18 or older and have a specific performance status as per the ECOG scale.
  • Participants must have confirmed multiple myeloma and meet certain measurable disease criteria.
  • Participants cannot join if they have certain health problems like severe asthma, heart disease, or if they recently had certain transplants.

This study helps doctors understand how AZD0305 works in treating RRMM and if it could be a new option for patients. Participants will receive the drug through an IV (intravenous) method. Joining the study involves regular hospital visits for monitoring.

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Study details
    Multiple Myeloma

NCT06106945

AstraZeneca

21 June 2025

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