This study is testing a treatment called indoximod for children and young adults aged 3 to 21 with certain brain tumors. Indoximod may help the body's immune system fight cancer by blocking a pathway called IDO, which normally helps tumors hide from the immune system. Researchers believe it might work better when combined with standard chemotherapy and radiation treatments.
The study is for patients with brain cancers like glioblastoma, medulloblastoma, or ependymoma, as well as newly diagnosed DIPG (a type of brain tumor). Participants will be placed in different cohorts based on their specific cancer and treatment needs. To join, patients must meet certain health criteria and cannot have had prior treatment with indoximod.
- Study Length and Visits: Participation involves regular visits for treatment and monitoring.
- Eligibility: Children and young adults with certain types of brain tumors, who meet health criteria.
- Risks: Potential side effects from indoximod, chemotherapy, and radiation. Discuss with your doctor.
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