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A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)

Exploring new treatments for depression when current meds aren't enough.

Recruiting
18-74 years
All
Phase N/A

This study is for people with **Major Depressive Disorder (MDD)** who feel little joy or pleasure (anhedonia) and aren't getting better with their current antidepressants like **SSRI** (Selective Serotonin Reuptake Inhibitor) or **SNRI** (Serotonin Norepinephrine Reuptake Inhibitor). The study will look at details about the people and how their treatments are working. You can join if you're starting a new treatment along with your current one to help with your depression. However, you can't join if you have psychotic disorders, bipolar disorder, or other serious health issues. Also, if you haven't improved at all with your current medicine, you may not qualify. This study will help understand the best ways to treat people with these symptoms.

  • The study involves starting a new treatment along with your current one.
  • Participants will be monitored closely to see how well treatments work.
  • This is an observational study, meaning no new experimental drugs will be given.

If you join, you will need to provide consent, which means you agree to let researchers collect and study your data safely and privately.

Study details
    Depressive Disorder
    Major

NCT05841030

Janssen Research & Development, LLC

26 July 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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