This study will check how well two medicines, **retatrutide** and **semaglutide**, work for people with Type 2 Diabetes. People in the study have to take metformin, a common diabetes medicine, and possibly another called SGLT2 inhibitor. The study lasts about 26 months and involves around 24 doctor visits. **Type 2 Diabetes (T2D)** is a condition where the body has trouble using insulin, a hormone that helps sugar enter cells to be used for energy. Some key things to know if you want to join:

• You must have Type 2 Diabetes and take metformin. Your blood sugar levels should be between 7.0% and 10.5%.
• People with certain health issues like severe heart problems or cancer can't join.
• The study will take about 26 months, and you’ll need to visit the clinic up to 24 times during this period.

Participants will help researchers understand how these diabetes medications work and if they are safe. Please consider your health and time commitment before deciding to take part.