This study is about using special cells from a donor's blood or bone marrow to help treat people with blood cancers, like leukemia. The donor's cells help the patient's body fight the cancer. The cells are from someone who is not related to the patient and might not completely match the patient’s tissue type, called **HLA-mismatched**. After the transplant, medicines like cyclophosphamide, tacrolimus, and mycophenolate mofetil are used to stop the patient's body from fighting the new cells, a problem called **graft versus host disease** (GVHD). This study is for adults and children with specific blood cancers who meet certain health criteria.

• The study involves different types of blood cancer patients, each with specific health requirements.
• Participants need to take particular medicines to prevent complications after the transplant.
• Must have a donor who is not related but partially matches in specific tissue types.