This study is testing a medicine called **ziltivekimab** to see if it can reduce heart problems, like heart attacks and strokes, in people with heart disease, kidney disease, and inflammation. **Ziltivekimab** is a new medicine, not yet approved anywhere, and will be compared to a **placebo** (a dummy medicine) to see if it works.

Participants will inject the medicine using a pre-filled syringe once a month for up to 4 years. The study involves up to 20 doctor visits where blood and urine samples will be taken. Doctors will also check participants’ hearts using **echocardiography** (sound waves) and an **electrocardiogram** (electrodes). Women who are pregnant or planning to become pregnant should not join this study.

• The study lasts up to 4 years with up to 20 clinic visits.
• Participants will use a pre-filled syringe to inject medicine monthly.
• Not suitable for pregnant women or those planning to get pregnant.