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Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder

Testing vagus nerve therapy for PTSD in veterans.

Recruiting
18-75 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at how a treatment called *transcutaneous cervical vagal nerve stimulation* (**tcVNS**) affects veterans with *Posttraumatic Stress Disorder* (**PTSD**). TcVNS is a way to stimulate a nerve in your neck using a small device. Veterans will have brain scans and other tests before and after using tcVNS or a fake treatment at home twice a day for three months. Positron Emission Tomography (**PET**), a special kind of brain scan, will be used to see how the brain reacts to stress. Researchers will also check blood for inflammation and how the body responds to stress.

The study uses a special kind of water that helps with brain scans and is safe to use. The device used in this study is called GammaCore and has been used before without any problems. The Food and Drug Administration (**FDA**) has approved this device for PTSD research. Veterans aged 18 to 75 with PTSD can participate if they don't have certain health issues or other conditions.

  • Study lasts three months with home treatments twice daily.
  • No serious side effects have been reported with the device.
  • Participants must not have certain medical conditions or substance abuse problems.
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Study details
    Stress Disorders
    Post-Traumatic

NCT05517304

VA Office of Research and Development

6 April 2025

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