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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

Exploring TX000045 for Pulmonary Hypertension and Heart Failure.

Recruiting
18-83 years
All
Phase 2

This study looks at how a medicine called TX000045 can help people with a special type of heart problem, called Pulmonary Hypertension with Heart Failure. This heart problem means your heart doesn't pump blood as well as it should. In the study, participants will get one of two doses of TX000045 or a placebo (a fake medicine) every two weeks for 24 weeks.

Key Points:

  • Participants will be part of the study for about 24 weeks, getting doses every two weeks.
  • The study needs about 180 people between the ages of 18 and 83 who have specific heart problems.
  • Some people can't join if they have other serious health issues or have used certain medicines recently.

To join, you must have a stable heart condition and be able to walk a certain distance. You should not have been in the hospital recently or have started a new exercise plan. If you think you meet the requirements, talk to your doctor about joining the study.

Study details
    Pulmonary Hypertension
    Heart Failure With Preserved Ejection Fraction

NCT06616974

Tectonic Therapeutic

7 March 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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