RGX-314 Gene Therapy Study is testing a new treatment for Diabetic Retinopathy (DR), a condition where high blood sugar affects the eye's retina, causing vision problems. In this study, a special treatment called gene therapy might help improve vision and reduce the need for frequent eye injections. Gene therapy works by delivering new genes to the eye to help it function better. The study has two parts. In Part 1, around 100 people will be tested, and in Part 2, 30 people will be tested. You might be chosen to receive the new treatment or just be watched. If you only get watched, you’ll have the chance to get the treatment later. Participants must be between 25-89 years old and meet certain health criteria.

• The study involves multiple visits and treatments over time.
• Participants may receive a steroid regimen for 7 weeks.
• Those not initially receiving the treatment will be offered it after the study ends.