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A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)

Testing KarXT's effects on Alzheimer's-related psychosis symptoms.

Recruiting
55-90 years
All
Phase 3

This study is testing if a drug called KarXT can help treat psychosis (seeing or believing things that aren't real) in people with Alzheimer's Disease (AD). The study is randomized (participants are chosen by chance) and double-blind (neither the participants nor the researchers know who gets the real drug or a fake one called a placebo). It's for people aged 55 to 90 who have mild to severe AD and psychosis.

Participants will be evaluated using a test called the Neuropsychiatric Inventory-Clinician (NPI-C), which checks for hallucinations (seeing things) and delusions (false beliefs).

  • To join, you need to live in the same place for at least 6 weeks and have a study partner who can visit or call you often.
  • You cannot join if you have other major mental health conditions or serious medical issues.
  • The study lasts a few months, and you'll need to attend several visits for tests and check-ups.

If successful, this study could offer a new way to help people with AD who experience difficult symptoms like hallucinations and delusions.

Study details
    Psychosis Associated With Alzheimer's Disease

NCT06126224

Karuna Therapeutics

9 March 2025

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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