This study looks at treating nerve damage in people with gastrointestinal (GI) cancers using a drug called **oxaliplatin**. This drug can cause nerve damage, so the study tests if giving it over 6 hours instead of 2 hours can help reduce this problem. The main goal is to see if the longer infusion time makes a difference in how bad the nerve damage gets. The study involves two groups: one group gets the drug over 2 hours, the other over 6 hours, alongside other chemotherapy medications like leucovorin and fluorouracil. The treatment cycles repeat every 14 days unless the disease progresses or side effects are too severe. After treatment, participants are checked at 1, 3, 6, 12, and 18 months.

• **Study Duration:** Treatment every 14 days, follow-up for up to 18 months.
• **Visits Required:** Regular check-ups and follow-up appointments.
• **Risks:** Potential for nerve damage and other chemotherapy side effects.