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Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies

Studying a new antibody treatment for advanced cancer patients.

Recruiting
18 years and older
All
Phase 1

This study is testing a new medicine called **TAB004**, which is a type of medicine known as a **monoclonal antibody** (a special protein made in labs to target and fight specific parts of cells) to see if it is safe and how it behaves in the body. It’s for people with advanced cancers that have not been cured by other treatments. The study will look at TAB004 alone and with another medicine called **toripalimab**. **BTLA** is a part of the immune system that this medicine targets, while **PD-1** is another immune part targeted by toripalimab.

Key Points:

  • The study could last up to 2 years with visits every 21 days.
  • Participants will receive TAB004 alone or with toripalimab through an **IV infusion** (medicine given through a vein).
  • Safety checks include health exams, blood tests, and watching for side effects.

Participants must be adults with certain types of cancers and meet health requirements. Risks may include immune system reactions or other side effects. Compensation is not mentioned, and it's important to discuss with the study team about participation.

Study details
    Advanced Unresectable Solid Tumor
    Metastatic Solid Tumor

NCT04137900

TopAlliance Biosciences

13 December 2024

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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