Necrotizing Fasciitis (NF) is a serious infection that affects the soft tissues in the body. This study tests two different treatments for NF: acellular fish skin graft (AFS) and the usual method called allograft human cadaver skin (AHC). The goal is to see which treatment helps the skin heal better and faster before a permanent skin transplant, called an autograft, is done.

The study will take place at the Joseph M. Still Burn Center or Advanced Wound Clinic in Augusta. To join, you must be 18 years or older and have a stable NF diagnosis. Pregnant women, those with certain autoimmune diseases, and cancer patients may not be eligible.

• This study is open-label, meaning both doctors and patients know which treatment is given.
• Participants will be randomly assigned to either AFS or AHC treatment groups.
• While there is no mention of payment, the focus is on improving the healing process.