In this study, researchers are testing a medicine called povetacicept to see if it helps people with a kidney problem called Immunoglobulin A Nephropathy (IgAN). IgAN is a disease where a protein called immunoglobulin A (IgA) builds up in the kidneys, causing damage. The study compares povetacicept to a placebo (a fake treatment) to check if it reduces protein in urine and helps kidneys work better.

You can join if you have confirmed IgAN, with high protein levels in your urine, and your kidneys still work at a certain level (eGFR ≥ 30 mL/min/1.73m²). You should be on stable kidney medications like ACE inhibitors (ACEi) or angiotensin II receptor blockers (ARBs). You cannot join if you've recently had certain treatments for your IgAN.

• You may need to stop other treatments for a while before starting.
• Expect to attend multiple visits during the study.
• Check if you will receive any compensation for participation.