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A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

Testing BMS-986393 for safety and effectiveness in multiple myeloma patients.

Recruiting
18 years and older
All
Phase 1

This study aims to find a safe dose of a new medicine called **BMS-986393** when used with other medicines in patients with **relapsed and/or refractory multiple myeloma (RRMM)**. Multiple myeloma is a type of blood cancer that affects plasma cells, which are a part of your immune system. "Relapsed" means the cancer has come back, and "refractory" means it didn't respond well to treatment.

Participants will receive BMS-986393 with other medicines: alnuctamab, mezigdomide, and iberdomide. To join, you should have RRMM treated with at least 1-3 treatments before. You need to be in good health, with a performance status of 0-1, which means you can carry out normal activities without assistance.

However, if you have any condition that makes it hard to understand the study results or have a history of multiple myeloma affecting your brain or spinal cord, you cannot join. There are more rules about who can join, which are not listed here.

  • The study involves trying new drug combinations.
  • Participants should have undergone previous treatments.
  • Good health condition is required for participation.
Study details
    Multiple Myeloma

NCT06121843

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

3 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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