ECMO (Extracorporeal Membrane Oxygenation) is a life support machine that helps critically ill children breathe. This study, called TITRE, looks at how giving red blood cell (RBC) transfusions based on specific needs can help children on ECMO. Usually, doctors give transfusions based on certain blood levels, but this study tests if giving transfusions only when needed for bleeding or low oxygen helps more. The study is for kids under 6 years old on ECMO for the first time.
The study will look at how these children do while on ECMO and up to a year later. The main goals are to see if kids have better organ function and development after a year.
- Duration: Up to 12 months with check-ins at 3, 6, 9, and 12 months.
- Eligibility: Children under 6 years, using specific ECMO types.
- Consider: No special blood conditions, not in another trial affecting development.
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