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Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

Join a study for patients with T-ALL or T-LBL.

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12 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)
Study Overview: This research study examines how well a drug called OBI-3424 works in patients with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL). These are cancers of the blood and lymph system that may not have responded to normal treatments. The study aims to find the safest dose of OBI-3424 and to see if it can help reduce cancer in the body by stopping cancer cells from growing or spreading. Key Points:
  • The study involves an initial dose-finding phase followed by a treatment phase where the drug is given every 21 days for up to 17 cycles.
  • Participants need to undergo tests like blood samples, bone marrow tests, and possibly scans. After treatment, they will have regular follow-ups for up to 5 years.
  • Eligible participants must be over 12 years old and have specific blood and health conditions. They should not have uncontrolled infections or be pregnant.
Participation Consideration: If you are eligible, this study might offer a new treatment option. However, consider the time commitment, potential side effects, and regular medical tests involved.
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Study details
    Recurrent T Acute Lymphoblastic Leukemia
    Refractory T Acute Lymphoblastic Leukemia
    Refractory T Lymphoblastic Lymphoma
    T Lymphoblastic Lymphoma

NCT04315324

SWOG Cancer Research Network

7 March 2026

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