Ponsegromab Study is a clinical trial for people with heart failure. Heart failure is when the heart doesn't pump blood as well as it should. This study compares a new medicine called Ponsegromab to a placebo, which is a shot that looks like the medicine but has no active ingredients. Most participants won't know if they get the real medicine or placebo. Participants will receive shots under the skin every four weeks for about 9 months and visit the clinic monthly. There is a special group in the study that only gets the real medicine for about 7 months. This group will also receive shots every four weeks.

• The study lasts about 9 months, with monthly clinic visits.
• Participants may receive either the study medicine or placebo.
• There are two parts of the study - one where you may not know what you're getting and one where you do.

To join, you must be over 18 and have heart failure. You cannot join if you've had recent heart surgery or other serious heart issues. This study checks the medicine's effects on heart failure symptoms and its safety.