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A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma

Comparing treatments for follicular lymphoma: Mosunetuzumab vs. Rituximab.

Recruiting
18 years and older
All
Phase 3

This study looks at how well and how safely two different treatment combinations work for people with follicular lymphoma (a type of blood cancer). Mosunetuzumab and lenalidomide (M + Len) are compared to rituximab and lenalidomide (R + Len). Participants have follicular lymphoma that hasn't responded well to other treatments. To join, patients need a certain health level (ECOG score of 0, 1, or 2), must have tried at least one other treatment, and can provide a tumor sample. Importantly, both men and women must agree to use birth control to prevent pregnancy during and after the study. Some conditions like a history of severe allergies or certain infections mean you can't participate.

  • Study Duration: Until the safety and effectiveness are thoroughly assessed.
  • Visits: Regular visits are required for monitoring and treatment.
  • Risks: Potential side effects from the combination treatments.
Study details
    Relapsed or Refractory Follicular Lymphoma

NCT04712097

Hoffmann-La Roche

5 January 2025

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