This study is for Black/African American and Hispanic people in the U.S. with *ASCVD*, a heart disease problem. We are testing a medicine called **pelacarsen** to see if it can lower a substance in the blood called *Lp(a)*, which can increase heart disease risk. Participants will receive either pelacarsen or a *placebo* (a harmless pill that looks like the real medicine) given as an injection under the skin once a month.

To join the study, you must be between 18 and 80 years old and already taking medicine for heart disease risk factors. You should have high Lp(a) levels and existing heart conditions like coronary heart disease or peripheral artery disease. You can't join if you have uncontrolled high blood pressure, severe heart failure, or other serious health issues.

• **Study Length:** The study is ongoing, with monthly injections.
• **Visits Needed:** Regular check-ups to monitor your health and progress.
• **Risks:** Possible side effects from the medicine or injections.

Consider these points and talk to your doctor to see if participating is right for you.