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A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Evaluating Ralinepag's effectiveness and safety for PAH patients.

Recruiting
18 years and older
All
Phase 3

The study is looking at how well a drug called **ralinepag** works and how safe it is for people with Pulmonary Arterial Hypertension (**PAH**). PAH is a serious condition where the blood vessels in the lungs become narrow, causing high blood pressure. The study will compare ralinepag to a placebo, which is a pill that looks like the real drug but has no medicine. People who join will be randomly assigned to take either ralinepag or the placebo, along with their regular PAH treatment.

**Key Points:**

  • The study lasts until the target number of events is reached, with an option to continue in an extension study.
  • Participants must visit the study site regularly for check-ups and tests.
  • People in the study will not know if they are receiving ralinepag or the placebo.

Eligible participants need to be 18 or older, have PAH, and be stable on their current PAH medications. People cannot join if they have other significant health issues like severe liver disease or recent cancer. Participants must also agree to use effective birth control during the study.

Study details
    PAH
    Pulmonary Hypertension
    Pulmonary Arterial Hypertension
    Hypertension
    Connective Tissue Diseases
    Familial Primary Pulmonary Hypertension
    Vascular Diseases
    Cardiovascular Diseases
    Hypertension
    Pulmonary
    Lung Diseases
    Respiratory Tract Disease

NCT03626688

United Therapeutics

27 April 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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