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A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Studying Mavacamten for heart muscle changes in certain heart conditions.

Recruiting
18 years and older
All
Phase 4
  • Simplified description (AI rewritten)
  • Technical description (Original)

A Study on Mavacamten for Heart Muscle Changes

This study looks at how a medicine called mavacamten affects the heart muscle in adults with a condition named obstructive hypertrophic cardiomyopathy (oHCM). In oHCM, the heart muscle is too thick, making it hard for blood to leave the heart. The study uses a special scan called cardiac magnetic resonance imaging (CMR) to see these changes. People in this study have symptoms that are classified as Class II or III by the New York Heart Association (NYHA), meaning they have noticeable difficulty with physical activity.

  • The study involves several visits for CMR scans and check-ups.
  • Participants must have certain heart conditions, like a specific heart muscle thickness.
  • People with certain heart devices or recent serious heart events cannot join.
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Study details
    Cardiomyopathy
    Hypertrophic

NCT06112743

Bristol-Myers Squibb

19 April 2025

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