This study looks at using a special **antibiotic-coated nail** to help prevent infections in people with serious leg bone (tibia) fractures. The study compares this new nail to the regular treatment method, which uses a nail without the special coating. An antibiotic is a medicine that fights infections caused by bacteria. The **intramedullary (IM) nail** is a rod placed inside the bone to help it heal. The study will run for **12 months**, with check-ins at the start, 6 weeks, 3 months, 6 months, and 12 months. It aims to see if the special nail can lower the number of deep infections, as these can lead to more hospital visits and sometimes even the need for amputation. This study is for people 18 years or older with certain types of open tibia fractures.

• Study lasts for **12 months** with several follow-up visits.
• Participants must be 18 or older with specific leg fractures.
• Some people, like those allergic to certain antibiotics, cannot join.