This study is looking at a new medicine called LOXO-435 to see if it's safe and works well for people with cancer. Some people in the study will take LOXO-435 alone, and others will take it with other cancer treatments. The medicine is for cancers where a gene called FGFR3 has changed. The study might last up to 30 months (2.5 years), and you can stay longer if your cancer doesn't get worse.

To join, your cancer needs to have a specific gene change, and you must have some tumor tissue available for testing. You should also be well enough to participate based on your activity level. Some people need to have tried other cancer treatments first, but not everyone.

• The study could last over two years, with multiple visits.
• It's important to have your cancer type and gene status checked.
• Check if you've had certain treatments before, as some are required or not allowed.

Please talk to your doctor about whether this study is right for you.