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FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

FORAGER-1: Testing LOXO-435 in cancer patients with FGFR3 gene changes.

Recruiting
18 years and older
All
Phase 1

This study is looking at a new medicine called LOXO-435 to see if it's safe and works well for people with cancer. Some people in the study will take LOXO-435 alone, and others will take it with other cancer treatments. The medicine is for cancers where a gene called FGFR3 has changed. The study might last up to 30 months (2.5 years), and you can stay longer if your cancer doesn't get worse.

To join, your cancer needs to have a specific gene change, and you must have some tumor tissue available for testing. You should also be well enough to participate based on your activity level. Some people need to have tried other cancer treatments first, but not everyone.

  • The study could last over two years, with multiple visits.
  • It's important to have your cancer type and gene status checked.
  • Check if you've had certain treatments before, as some are required or not allowed.

Please talk to your doctor about whether this study is right for you.

Study details
    Urinary Bladder Neoplasms
    Neoplasm Metastasis
    Ureteral Neoplasms

NCT05614739

Eli Lilly and Company

5 July 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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