Image

Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD

Evaluating COMP360's effects for treatment-resistant depression patients.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study explores how well COMP360, a medicine, works for people with treatment-resistant depression (TRD). TRD is when depression doesn't get better after trying at least two different medicines. The study involves 255 adults, split into two groups: two-thirds get COMP360, and one-third get a placebo (a fake treatment). The study lasts around 62 weeks and has three parts: A, B, and C.

In Part A, participants will get a single dose of COMP360 or placebo and be monitored for six weeks. Part B and C will check how well COMP360 works over a longer time and if it’s safe to use again. Participants must be at least 18 years old and have tried other depression treatments without success.

  • Study duration: About 62 weeks.
  • Participants: Must be 18+ with previous depression treatment failures.
  • Risks: Participants cannot have certain mental health conditions or treatments.
Print
Study details
    Treatment Resistant Depression

NCT05624268

COMPASS Pathways

17 December 2024

Contact a study center
Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.