This study aims to compare two treatments for people with atrial fibrillation (AF), a common heart rhythm problem. One group will use the Amulet LAA occluder, a device that blocks a small part of the heart to prevent clots, and the other group will take a medication called NOAC (Non-Vitamin K Oral Anticoagulants), which helps prevent strokes by thinning the blood.

To join, you must be 18 or older, have AF, and be able to take NOACs or have the device implanted. You should be at a high risk for stroke, as shown by a specific score (CHA₂DS₂-VASc). You can't join if you need other blood thinners, have had recent heart problems, or have certain medical conditions.

• The study is worldwide and will randomly assign participants to one of the two groups.
• Participants must visit the doctor for follow-ups, and the study might last for a few years.
• There may be risks like infection or reactions to the device or medication.

Consider if you can attend regular check-ups and if you meet the health criteria before deciding to participate.