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A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

Join a study on Repotrectinib for advanced solid tumors.

Recruiting
12 years and older
All
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study tests a new medicine called Repotrectinib for patients with advanced tumors. Tumors are growths that can be harmful, and "advanced" means they are severe and have spread. The tumors in this study have changes in genes like ALK, ROS1, or NTRK1-3. Genes are like instructions for our body, and sometimes they change, causing diseases.

The study has two parts. In Phase 1, they find the safe dose of the medicine. In Phase 2, they see how well the medicine works. Some patients will also take another medicine called Midazolam to see how the two medicines work together.

Participants must be at least 18 years old and able to swallow capsules. Some may need to send tissue samples for testing. The study will check how long patients respond to treatment and their overall survival.

  • The study has multiple groups (6 in total) based on previous treatments.
  • Participants must have specific gene changes and meet health requirements.
  • Treatment length and visits depend on the group you join.
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Study details
    Locally Advanced Solid Tumors
    Metastatic Solid Tumors

NCT03093116

Turning Point Therapeutics, Inc.

11 May 2025

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Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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